Assay Detail
Binding
CHEMBL5331914
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Inhibition of HIV-1 RNase H
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Current medicinal chemistry strategies in the discovery of novel HIV-1 ribonuclease H inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.20 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080764 | — | — | 1 | 6.89 |
| CHEMBL550937 | BETA-THUJAPLICINOL | — | 1 | 6.68 |
| CHEMBL1997963 | — | — | 1 | 6.22 |
| CHEMBL5401719 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080764 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL550937 | BETA-THUJAPLICINOL | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1997963 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5401719 | — | IC50 | = | 10000.0 | nM | 5.00 |