Assay Detail

CHEMBL5331967

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiproliferative activity against human K562 cells assessed as inhibition of cell growth

ChEMBL ↗

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Target

K562 (CHEMBL385) ↗

Open DB target context

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Primary target K562

CHEMBL385

Anchored from Assay target.

Protein identity K562

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	K562
Confidence	1 — Organism
Curated By	Autocuration

Target

K562 (CHEMBL385) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

Gu J, Wu Q, Zhang Q, You Q, Wang L.
Eur J Med Chem (2022) 243 : 114742 -114742
PubMed 36155354 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.68	7.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL46286	OMACETAXINE MEPESUCCINATE	4.0	1	7.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL46286	OMACETAXINE MEPESUCCINATE	IC50	=	21.0	nM	7.68