Assay Detail

CHEMBL5332001

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Functional

Antiproliferative activity against rat RBL-2H3 cells assessed as inhibition of growth inhibition

ChEMBL ↗

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Target

RBL-2H3 (CHEMBL614632) ↗

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RBL-2H3 (CHEMBL614632) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target RBL-2H3

CHEMBL614632

Anchored from Assay target.

Protein identity RBL-2H3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	RBL-2H3
Confidence	1 — Organism
Curated By	Autocuration

Target

RBL-2H3 (CHEMBL614632) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.

Gu J, Wu Q, Zhang Q, You Q, Wang L.
Eur J Med Chem (2022) 243 : 114742 -114742
PubMed 36155354 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.40	6.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3348963	TELOTRISTAT ETIPRATE	4.0	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3348963	TELOTRISTAT ETIPRATE	IC50	=	400.0	nM	6.40