Assay Detail
Binding
CHEMBL5332019
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Inhibition of XPO1 in human MOLT-16 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLT-16 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.21 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545185 | SELINEXOR | 4.0 | 1 | 7.47 |
| CHEMBL3898452 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545185 | SELINEXOR | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3898452 | — | IC50 | = | 112.0 | nM | 6.95 |