Assay Detail
Functional
CHEMBL5332075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.80 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.70 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.85 |
| CHEMBL5410271 | — | — | 1 | 6.38 |
| CHEMBL5414224 | — | — | 1 | 6.28 |
| CHEMBL5403201 | — | — | 1 | 6.13 |
| CHEMBL5397291 | — | — | 1 | 6.09 |
| CHEMBL5419960 | — | — | 1 | 5.95 |
| CHEMBL5424018 | — | — | 1 | 5.94 |
| CHEMBL5427838 | — | — | 1 | 5.93 |
| CHEMBL5394658 | — | — | 1 | 5.84 |
| CHEMBL5413173 | — | — | 1 | 5.79 |
| CHEMBL5402895 | — | — | 1 | 5.75 |
| CHEMBL5430546 | — | — | 1 | 5.75 |
| CHEMBL5438500 | — | — | 1 | 5.75 |
| CHEMBL5404135 | — | — | 1 | 5.73 |
| CHEMBL5418524 | — | — | 1 | 5.71 |
| CHEMBL5416748 | — | — | 1 | 5.66 |
| CHEMBL5410383 | — | — | 1 | 5.64 |
| CHEMBL5431323 | — | — | 1 | 5.63 |
| CHEMBL5427111 | — | — | 1 | 5.55 |
| CHEMBL5407719 | — | — | 1 | 5.51 |
| CHEMBL5435756 | — | — | 1 | 5.50 |
| CHEMBL5417018 | — | — | 1 | 5.46 |
| CHEMBL5394426 | — | — | 1 | 5.41 |
| CHEMBL5427893 | — | — | 1 | 5.41 |
| CHEMBL5409808 | — | — | 1 | 5.40 |
| CHEMBL5402207 | — | — | 1 | 5.40 |
| CHEMBL5396592 | — | — | 1 | 5.39 |
| CHEMBL5417347 | — | — | 1 | 5.38 |
| CHEMBL5403963 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5410271 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL5414224 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL5403201 | — | IC50 | = | 749.0 | nM | 6.13 |
| CHEMBL5397291 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL5419960 | — | IC50 | = | 1127.0 | nM | 5.95 |
| CHEMBL5424018 | — | IC50 | = | 1137.0 | nM | 5.94 |
| CHEMBL5427838 | — | IC50 | = | 1167.0 | nM | 5.93 |
| CHEMBL5394658 | — | IC50 | = | 1437.0 | nM | 5.84 |
| CHEMBL5413173 | — | IC50 | = | 1627.0 | nM | 5.79 |
| CHEMBL5402895 | — | IC50 | = | 1768.0 | nM | 5.75 |
| CHEMBL5430546 | — | IC50 | = | 1797.0 | nM | 5.75 |
| CHEMBL5438500 | — | IC50 | = | 1759.0 | nM | 5.75 |
| CHEMBL5404135 | — | IC50 | = | 1854.0 | nM | 5.73 |
| CHEMBL5418524 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL5416748 | — | IC50 | = | 2209.0 | nM | 5.66 |
| CHEMBL5410383 | — | IC50 | = | 2267.0 | nM | 5.64 |
| CHEMBL5431323 | — | IC50 | = | 2353.0 | nM | 5.63 |
| CHEMBL5427111 | — | IC50 | = | 2837.0 | nM | 5.55 |
| CHEMBL5407719 | — | IC50 | = | 3105.0 | nM | 5.51 |
| CHEMBL5435756 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5417018 | — | IC50 | = | 3451.0 | nM | 5.46 |
| CHEMBL5394426 | — | IC50 | = | 3886.0 | nM | 5.41 |
| CHEMBL5427893 | — | IC50 | = | 3867.0 | nM | 5.41 |
| CHEMBL5409808 | — | IC50 | = | 3968.0 | nM | 5.40 |
| CHEMBL5402207 | — | IC50 | = | 3997.0 | nM | 5.40 |
| CHEMBL5396592 | — | IC50 | = | 4055.0 | nM | 5.39 |
| CHEMBL5417347 | — | IC50 | = | 4187.0 | nM | 5.38 |
| CHEMBL5403963 | — | IC50 | = | 4233.0 | nM | 5.37 |
| CHEMBL5408109 | — | IC50 | = | 4430.0 | nM | 5.35 |
| CHEMBL5432564 | — | IC50 | = | 4873.0 | nM | 5.31 |
| CHEMBL5415983 | — | IC50 | = | 4871.0 | nM | 5.31 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 9531.0 | nM | 5.02 |
| CHEMBL5395425 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5433153 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5394442 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5412419 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5413243 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406352 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5433969 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406383 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5426418 | — | IC50 | = | 3291000.0 | nM | - |
| CHEMBL5419725 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5400424 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5402349 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5416395 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5411389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5404863 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5431808 | — | IC50 | > | 5000.0 | nM | - |