Assay Detail
Functional
CHEMBL5332076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 5.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL5438500 | — | — | 1 | 6.42 |
| CHEMBL5419960 | — | — | 1 | 6.34 |
| CHEMBL5394658 | — | — | 1 | 6.29 |
| CHEMBL5416748 | — | — | 1 | 5.99 |
| CHEMBL5432564 | — | — | 1 | 5.99 |
| CHEMBL5427893 | — | — | 1 | 5.90 |
| CHEMBL5426418 | — | — | 1 | 5.84 |
| CHEMBL5410271 | — | — | 1 | 5.83 |
| CHEMBL5417347 | — | — | 1 | 5.82 |
| CHEMBL5403963 | — | — | 1 | 5.82 |
| CHEMBL5430546 | — | — | 1 | 5.77 |
| CHEMBL5396592 | — | — | 1 | 5.76 |
| CHEMBL5427111 | — | — | 1 | 5.76 |
| CHEMBL5401779 | — | — | 1 | 5.76 |
| CHEMBL5403201 | — | — | 1 | 5.76 |
| CHEMBL5394442 | — | — | 1 | 5.72 |
| CHEMBL5431323 | — | — | 1 | 5.72 |
| CHEMBL5415983 | — | — | 1 | 5.72 |
| CHEMBL5410383 | — | — | 1 | 5.71 |
| CHEMBL5397291 | — | — | 1 | 5.71 |
| CHEMBL5402207 | — | — | 1 | 5.70 |
| CHEMBL5395425 | — | — | 1 | 5.65 |
| CHEMBL5407719 | — | — | 1 | 5.64 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.64 |
| CHEMBL5402895 | — | — | 1 | 5.64 |
| CHEMBL5409808 | — | — | 1 | 5.63 |
| CHEMBL5394426 | — | — | 1 | 5.61 |
| CHEMBL5435756 | — | — | 1 | 5.56 |
| CHEMBL5424018 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5438500 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL5419960 | — | IC50 | = | 458.0 | nM | 6.34 |
| CHEMBL5394658 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL5416748 | — | IC50 | = | 1029.0 | nM | 5.99 |
| CHEMBL5432564 | — | IC50 | = | 1034.0 | nM | 5.99 |
| CHEMBL5427893 | — | IC50 | = | 1263.0 | nM | 5.90 |
| CHEMBL5426418 | — | IC50 | = | 1431.0 | nM | 5.84 |
| CHEMBL5410271 | — | IC50 | = | 1489.0 | nM | 5.83 |
| CHEMBL5417347 | — | IC50 | = | 1513.0 | nM | 5.82 |
| CHEMBL5403963 | — | IC50 | = | 1514.0 | nM | 5.82 |
| CHEMBL5430546 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5401779 | — | IC50 | = | 1743.0 | nM | 5.76 |
| CHEMBL5396592 | — | IC50 | = | 1721.0 | nM | 5.76 |
| CHEMBL5427111 | — | IC50 | = | 1734.0 | nM | 5.76 |
| CHEMBL5403201 | — | IC50 | = | 1735.0 | nM | 5.76 |
| CHEMBL5394442 | — | IC50 | = | 1922.0 | nM | 5.72 |
| CHEMBL5431323 | — | IC50 | = | 1906.0 | nM | 5.72 |
| CHEMBL5415983 | — | IC50 | = | 1903.0 | nM | 5.72 |
| CHEMBL5410383 | — | IC50 | = | 1939.0 | nM | 5.71 |
| CHEMBL5397291 | — | IC50 | = | 1961.0 | nM | 5.71 |
| CHEMBL5402207 | — | IC50 | = | 2012.0 | nM | 5.70 |
| CHEMBL5395425 | — | IC50 | = | 2238.0 | nM | 5.65 |
| CHEMBL5402895 | — | IC50 | = | 2307.0 | nM | 5.64 |
| CHEMBL5407719 | — | IC50 | = | 2271.0 | nM | 5.64 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 2285.0 | nM | 5.64 |
| CHEMBL5409808 | — | IC50 | = | 2319.0 | nM | 5.63 |
| CHEMBL5394426 | — | IC50 | = | 2447.0 | nM | 5.61 |
| CHEMBL5435756 | — | IC50 | = | 2765.0 | nM | 5.56 |
| CHEMBL5424018 | — | IC50 | = | 2933.0 | nM | 5.53 |
| CHEMBL5413173 | — | IC50 | = | 3083.0 | nM | 5.51 |
| CHEMBL5418524 | — | IC50 | = | 3222.0 | nM | 5.49 |
| CHEMBL5413243 | — | IC50 | = | 3288.0 | nM | 5.48 |
| CHEMBL5427838 | — | IC50 | = | 3367.0 | nM | 5.47 |
| CHEMBL5404135 | — | IC50 | = | 3426.0 | nM | 5.46 |
| CHEMBL5417018 | — | IC50 | = | 4461.0 | nM | 5.35 |
| CHEMBL5408109 | — | IC50 | = | 4527.0 | nM | 5.34 |
| CHEMBL5414224 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL5404863 | — | IC50 | = | 4994.0 | nM | 5.30 |
| CHEMBL5433153 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5419725 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5400424 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406844 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5402349 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406352 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5416395 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5412419 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5411389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5431808 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5433969 | — | IC50 | > | 5000.0 | nM | - |