Assay Detail
Functional
CHEMBL5332077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 6.26 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.52 |
| CHEMBL5419960 | — | — | 1 | 7.85 |
| CHEMBL5410383 | — | — | 1 | 6.99 |
| CHEMBL5438500 | — | — | 1 | 6.98 |
| CHEMBL5394442 | — | — | 1 | 6.86 |
| CHEMBL5408109 | — | — | 1 | 6.60 |
| CHEMBL5427893 | — | — | 1 | 6.50 |
| CHEMBL5417347 | — | — | 1 | 6.39 |
| CHEMBL5416748 | — | — | 1 | 6.36 |
| CHEMBL5432564 | — | — | 1 | 6.29 |
| CHEMBL5395425 | — | — | 1 | 6.26 |
| CHEMBL5402207 | — | — | 1 | 6.24 |
| CHEMBL5435756 | — | — | 1 | 6.24 |
| CHEMBL5410271 | — | — | 1 | 6.19 |
| CHEMBL5415983 | — | — | 1 | 6.19 |
| CHEMBL5396592 | — | — | 1 | 6.17 |
| CHEMBL5403963 | — | — | 1 | 6.14 |
| CHEMBL5401779 | — | — | 1 | 6.13 |
| CHEMBL5403201 | — | — | 1 | 6.12 |
| CHEMBL5402895 | — | — | 1 | 6.06 |
| CHEMBL5397291 | — | — | 1 | 6.01 |
| CHEMBL5418524 | — | — | 1 | 5.93 |
| CHEMBL5394658 | — | — | 1 | 5.91 |
| CHEMBL465843 | PIPLARTINE | — | 1 | 5.78 |
| CHEMBL5427111 | — | — | 1 | 5.73 |
| CHEMBL5413173 | — | — | 1 | 5.72 |
| CHEMBL5417018 | — | — | 1 | 5.67 |
| CHEMBL5404135 | — | — | 1 | 5.67 |
| CHEMBL5424018 | — | — | 1 | 5.62 |
| CHEMBL5427838 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5419960 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5410383 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5438500 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5394442 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL5408109 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL5427893 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5417347 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL5416748 | — | IC50 | = | 441.0 | nM | 6.36 |
| CHEMBL5432564 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL5395425 | — | IC50 | = | 546.0 | nM | 6.26 |
| CHEMBL5402207 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL5435756 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL5415983 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL5410271 | — | IC50 | = | 647.0 | nM | 6.19 |
| CHEMBL5396592 | — | IC50 | = | 682.0 | nM | 6.17 |
| CHEMBL5403963 | — | IC50 | = | 723.0 | nM | 6.14 |
| CHEMBL5401779 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5403201 | — | IC50 | = | 766.0 | nM | 6.12 |
| CHEMBL5402895 | — | IC50 | = | 866.0 | nM | 6.06 |
| CHEMBL5397291 | — | IC50 | = | 982.0 | nM | 6.01 |
| CHEMBL5418524 | — | IC50 | = | 1167.0 | nM | 5.93 |
| CHEMBL5394658 | — | IC50 | = | 1228.0 | nM | 5.91 |
| CHEMBL465843 | PIPLARTINE | IC50 | = | 1671.0 | nM | 5.78 |
| CHEMBL5427111 | — | IC50 | = | 1873.0 | nM | 5.73 |
| CHEMBL5413173 | — | IC50 | = | 1898.0 | nM | 5.72 |
| CHEMBL5404135 | — | IC50 | = | 2136.0 | nM | 5.67 |
| CHEMBL5417018 | — | IC50 | = | 2136.0 | nM | 5.67 |
| CHEMBL5424018 | — | IC50 | = | 2377.0 | nM | 5.62 |
| CHEMBL5427838 | — | IC50 | = | 3084.0 | nM | 5.51 |
| CHEMBL5414224 | — | IC50 | = | 4138.0 | nM | 5.38 |
| CHEMBL5404863 | — | IC50 | = | 4957.0 | nM | 5.30 |
| CHEMBL5433969 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406352 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406844 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5433153 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5430546 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5394426 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5407719 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5419725 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5431808 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5406383 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5424769 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5431323 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5411389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5416395 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5426418 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5402349 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5409808 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5400424 | — | IC50 | > | 5000.0 | nM | - |