Assay Detail
Functional
CHEMBL5332079
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Antiproliferative activity against human MCF-7/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-7/Taxol |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.35 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419960 | — | — | 1 | 6.48 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419960 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 618.0 | nM | 6.21 |