Assay Detail
Binding
CHEMBL5332254
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Inhibition of PLK1 (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of Wee1 kinase degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.67 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.57 |
| CHEMBL5403604 | — | — | 1 | 6.29 |
| CHEMBL5403903 | — | — | 1 | 5.92 |
| CHEMBL5434663 | — | — | 1 | 5.68 |
| CHEMBL5432090 | — | — | 1 | 5.68 |
| CHEMBL5440440 | — | — | 1 | 5.67 |
| CHEMBL5440332 | — | — | 1 | 5.63 |
| CHEMBL5406356 | — | — | 1 | 5.62 |
| CHEMBL5431802 | — | — | 1 | 5.53 |
| CHEMBL5427326 | — | — | 1 | 5.46 |
| CHEMBL5420142 | — | — | 1 | 5.42 |
| CHEMBL5393910 | — | — | 1 | 5.36 |
| CHEMBL5414912 | — | — | 1 | 5.27 |
| CHEMBL5405576 | — | — | 1 | 5.26 |
| CHEMBL5412194 | — | — | 1 | - |
| CHEMBL5425172 | — | — | 1 | - |
| CHEMBL5412009 | — | — | 1 | - |
| CHEMBL5421561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 267.7 | nM | 6.57 |
| CHEMBL5403604 | — | IC50 | = | 515.55 | nM | 6.29 |
| CHEMBL5403903 | — | IC50 | = | 1195.0 | nM | 5.92 |
| CHEMBL5434663 | — | IC50 | = | 2085.5 | nM | 5.68 |
| CHEMBL5432090 | — | IC50 | = | 2070.5 | nM | 5.68 |
| CHEMBL5440440 | — | IC50 | = | 2153.0 | nM | 5.67 |
| CHEMBL5440332 | — | IC50 | = | 2348.0 | nM | 5.63 |
| CHEMBL5406356 | — | IC50 | = | 2427.5 | nM | 5.62 |
| CHEMBL5431802 | — | IC50 | = | 2974.0 | nM | 5.53 |
| CHEMBL5427326 | — | IC50 | = | 3432.0 | nM | 5.46 |
| CHEMBL5420142 | — | IC50 | = | 3765.0 | nM | 5.42 |
| CHEMBL5393910 | — | IC50 | = | 4378.5 | nM | 5.36 |
| CHEMBL5414912 | — | IC50 | = | 5409.0 | nM | 5.27 |
| CHEMBL5405576 | — | IC50 | = | 5536.5 | nM | 5.26 |
| CHEMBL5412194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5425172 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412009 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5421561 | — | IC50 | > | 10000.0 | nM | - |