Assay Detail
Functional
CHEMBL5332255
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Antiproliferative activity against human MV4-11 cells assessed as cell growth inhibition measured after 72 hrs by SRB Assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of Wee1 kinase degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.10 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431802 | — | — | 1 | 7.34 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.88 |
| CHEMBL5393910 | — | — | 1 | 6.74 |
| CHEMBL5406356 | — | — | 1 | 6.67 |
| CHEMBL5440440 | — | — | 1 | 6.64 |
| CHEMBL5403604 | — | — | 1 | 6.39 |
| CHEMBL5434663 | — | — | 1 | 6.28 |
| CHEMBL5425172 | — | — | 1 | 6.14 |
| CHEMBL5403903 | — | — | 1 | 6.09 |
| CHEMBL5412009 | — | — | 1 | 6.00 |
| CHEMBL5414912 | — | — | 1 | 5.96 |
| CHEMBL5420142 | — | — | 1 | 5.95 |
| CHEMBL5432090 | — | — | 1 | 5.70 |
| CHEMBL5412194 | — | — | 1 | 5.67 |
| CHEMBL5440332 | — | — | 1 | 5.66 |
| CHEMBL5427326 | — | — | 1 | 5.30 |
| CHEMBL5421561 | — | — | 1 | 5.22 |
| CHEMBL5405576 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431802 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 132.6 | nM | 6.88 |
| CHEMBL5393910 | — | IC50 | = | 181.67 | nM | 6.74 |
| CHEMBL5406356 | — | IC50 | = | 214.53 | nM | 6.67 |
| CHEMBL5440440 | — | IC50 | = | 226.47 | nM | 6.64 |
| CHEMBL5403604 | — | IC50 | = | 407.63 | nM | 6.39 |
| CHEMBL5434663 | — | IC50 | = | 523.3 | nM | 6.28 |
| CHEMBL5425172 | — | IC50 | = | 716.1 | nM | 6.14 |
| CHEMBL5403903 | — | IC50 | = | 809.4 | nM | 6.09 |
| CHEMBL5412009 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5414912 | — | IC50 | = | 1105.13 | nM | 5.96 |
| CHEMBL5420142 | — | IC50 | = | 1126.67 | nM | 5.95 |
| CHEMBL5432090 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5412194 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5440332 | — | IC50 | = | 2201.0 | nM | 5.66 |
| CHEMBL5427326 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5421561 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5405576 | — | IC50 | = | 7000.0 | nM | 5.16 |