Assay Detail
Functional
CHEMBL5332256
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Antiproliferative activity against human SUM149PT cells assessed as cell growth inhibition measured after 72 hrs by SRB Assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SUM149PT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of Wee1 kinase degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.74 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5431802 | — | — | 1 | 6.66 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.27 |
| CHEMBL5393910 | — | — | 1 | 5.90 |
| CHEMBL5406356 | — | — | 1 | 5.81 |
| CHEMBL5440440 | — | — | 1 | 5.80 |
| CHEMBL5403903 | — | — | 1 | 5.67 |
| CHEMBL5414912 | — | — | 1 | 5.55 |
| CHEMBL5403604 | — | — | 1 | 5.50 |
| CHEMBL5412009 | — | — | 1 | 5.22 |
| CHEMBL5434663 | — | — | 1 | 5.05 |
| CHEMBL5425172 | — | — | 1 | - |
| CHEMBL5420142 | — | — | 1 | - |
| CHEMBL5421561 | — | — | 1 | - |
| CHEMBL5432090 | — | — | 1 | - |
| CHEMBL5427326 | — | — | 1 | - |
| CHEMBL5405576 | — | — | 1 | - |
| CHEMBL5412194 | — | — | 1 | - |
| CHEMBL5440332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5431802 | — | IC50 | = | 217.67 | nM | 6.66 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 536.2 | nM | 6.27 |
| CHEMBL5393910 | — | IC50 | = | 1256.67 | nM | 5.90 |
| CHEMBL5406356 | — | IC50 | = | 1548.33 | nM | 5.81 |
| CHEMBL5440440 | — | IC50 | = | 1591.33 | nM | 5.80 |
| CHEMBL5403903 | — | IC50 | = | 2127.67 | nM | 5.67 |
| CHEMBL5414912 | — | IC50 | = | 2809.67 | nM | 5.55 |
| CHEMBL5403604 | — | IC50 | = | 3137.33 | nM | 5.50 |
| CHEMBL5412009 | — | IC50 | = | 6038.0 | nM | 5.22 |
| CHEMBL5434663 | — | IC50 | = | 8847.33 | nM | 5.05 |
| CHEMBL5425172 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5420142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5421561 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5432090 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5427326 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405576 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5440332 | — | IC50 | > | 10000.0 | nM | - |