Assay Detail
Functional
CHEMBL5332400
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 5.79 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399106 | — | — | 1 | 6.62 |
| CHEMBL5416448 | — | — | 1 | 6.38 |
| CHEMBL5418695 | — | — | 1 | 6.37 |
| CHEMBL5434626 | — | — | 1 | 6.31 |
| CHEMBL5402344 | — | — | 1 | 6.29 |
| CHEMBL5413000 | — | — | 1 | 6.28 |
| CHEMBL5410523 | — | — | 1 | 6.23 |
| CHEMBL5418936 | — | — | 1 | 6.21 |
| CHEMBL5424823 | — | — | 1 | 6.19 |
| CHEMBL5406583 | — | — | 1 | 6.18 |
| CHEMBL5414056 | — | — | 1 | 6.04 |
| CHEMBL5394600 | — | — | 1 | 6.00 |
| CHEMBL5436704 | — | — | 1 | 5.99 |
| CHEMBL5440733 | — | — | 1 | 5.96 |
| CHEMBL5395752 | — | — | 1 | 5.94 |
| CHEMBL5440176 | — | — | 1 | 5.90 |
| CHEMBL5422333 | — | — | 1 | 5.89 |
| CHEMBL5431676 | — | — | 1 | 5.89 |
| CHEMBL5412747 | — | — | 1 | 5.86 |
| CHEMBL5420954 | — | — | 1 | 5.85 |
| CHEMBL5410992 | — | — | 1 | 5.84 |
| CHEMBL5438694 | — | — | 1 | 5.84 |
| CHEMBL5432886 | — | — | 1 | 5.83 |
| CHEMBL5408565 | — | — | 1 | 5.76 |
| CHEMBL5417760 | — | — | 1 | 5.76 |
| CHEMBL5436596 | — | — | 1 | 5.74 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.61 |
| CHEMBL5420058 | — | — | 1 | 5.58 |
| CHEMBL5409830 | — | — | 1 | 5.53 |
| CHEMBL5409321 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399106 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5416448 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5418695 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5434626 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5402344 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5413000 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5410523 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5418936 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5424823 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5406583 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5414056 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5394600 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5436704 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5440733 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5395752 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5440176 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5422333 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5431676 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5412747 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL5420954 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5410992 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5438694 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5432886 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5408565 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5417760 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL5436596 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5420058 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL5409830 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5409321 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL5423136 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL5435909 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL5432005 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL5426471 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL5432519 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5410667 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL5395429 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL5403601 | — | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL5431600 | — | IC50 | = | 7960.0 | nM | 5.10 |
| CHEMBL5402253 | — | IC50 | = | 13090.0 | nM | 4.88 |
| CHEMBL5427531 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5410777 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5429362 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5433541 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5407960 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5401609 | — | IC50 | > | 20000.0 | nM | - |