Assay Detail
Functional
CHEMBL5332402
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Anticancer activity against human MDA-MB-238 cells assessed as cell growth inhibition measured after 72 hrs by CCK-8 staining based microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-238 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.90 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5399106 | — | — | 1 | 6.35 |
| CHEMBL5416448 | — | — | 1 | 6.05 |
| CHEMBL5413000 | — | — | 1 | 5.87 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5399106 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5416448 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5413000 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4920.0 | nM | 5.31 |