Assay Detail
Binding
CHEMBL5332409
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Inhibition of human HDAC8 using Boc-Lys (trifluoroacety1)-AMC as substrate pretreated with compound for 1 hrs followed by substrate addition measured after 1 hrs by microplate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.37 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413000 | — | — | 1 | 6.59 |
| CHEMBL5416448 | — | — | 1 | 6.55 |
| CHEMBL5399106 | — | — | 1 | 6.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413000 | — | IC50 | = | 255.89 | nM | 6.59 |
| CHEMBL5416448 | — | IC50 | = | 281.32 | nM | 6.55 |
| CHEMBL5399106 | — | IC50 | = | 302.73 | nM | 6.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1560.72 | nM | 5.81 |