Assay Detail
Binding
CHEMBL5332682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATR (unknown origin) using peptide as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysis
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 7.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424025 | — | — | 1 | 8.70 |
| CHEMBL5432859 | — | — | 1 | 8.70 |
| CHEMBL5422058 | — | — | 1 | 8.52 |
| CHEMBL5423608 | — | — | 1 | 8.52 |
| CHEMBL5412749 | — | — | 1 | 8.40 |
| CHEMBL5427147 | — | — | 1 | 8.40 |
| CHEMBL5415921 | — | — | 1 | 8.40 |
| CHEMBL5408725 | — | — | 1 | 8.40 |
| CHEMBL2325697 | — | — | 1 | 8.30 |
| CHEMBL5425498 | — | — | 1 | 8.30 |
| CHEMBL5423097 | — | — | 1 | 8.30 |
| CHEMBL5416225 | — | — | 1 | 8.30 |
| CHEMBL5412022 | — | — | 1 | 8.22 |
| CHEMBL5412393 | — | — | 1 | 8.22 |
| CHEMBL5426255 | — | — | 1 | 8.15 |
| CHEMBL5396739 | — | — | 1 | 8.15 |
| CHEMBL5406541 | — | — | 1 | 8.10 |
| CHEMBL5398150 | — | — | 1 | 8.10 |
| CHEMBL5401874 | — | — | 1 | 8.10 |
| CHEMBL5423544 | — | — | 1 | 8.05 |
| CHEMBL5426919 | — | — | 1 | 8.05 |
| CHEMBL5425941 | — | — | 1 | 8.05 |
| CHEMBL5419225 | — | — | 1 | 8.05 |
| CHEMBL5439160 | — | — | 1 | 8.00 |
| CHEMBL5399603 | — | — | 1 | 7.92 |
| CHEMBL5440718 | — | — | 1 | 7.89 |
| CHEMBL5393965 | — | — | 1 | 7.85 |
| CHEMBL5419053 | — | — | 1 | 7.85 |
| CHEMBL5398694 | — | — | 1 | 7.82 |
| CHEMBL5424546 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424025 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5432859 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5423608 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5422058 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5412749 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5427147 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5415921 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5408725 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2325697 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5425498 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5423097 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5416225 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5412022 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5412393 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5396739 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5426255 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5406541 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5398150 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5401874 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5423544 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5426919 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5425941 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5419225 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5439160 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5399603 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5440718 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5419053 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5393965 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5398694 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5424546 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5399632 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5395664 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5435065 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5402160 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5428095 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5419395 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5395004 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5406878 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5423295 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5420569 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5418740 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5398034 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5439862 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5433823 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5438125 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5415262 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5428343 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5404032 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5410944 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5431596 | — | IC50 | = | 72.0 | nM | 7.14 |