Assay Detail
Functional
CHEMBL5332686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against ATM-proficient human HT-29 cells assessed as reduction in cell proliferation incubated for 3 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.10 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423608 | — | — | 1 | 6.71 |
| CHEMBL5412393 | — | — | 1 | 6.51 |
| CHEMBL5427147 | — | — | 1 | 6.45 |
| CHEMBL5422058 | — | — | 1 | 6.41 |
| CHEMBL5425498 | — | — | 1 | 6.38 |
| CHEMBL5412749 | — | — | 1 | 6.37 |
| CHEMBL5408725 | — | — | 1 | 6.35 |
| CHEMBL5415921 | — | — | 1 | 6.31 |
| CHEMBL2325697 | — | — | 1 | 6.19 |
| CHEMBL5419225 | — | — | 1 | 5.79 |
| CHEMBL5425941 | — | — | 1 | 5.61 |
| CHEMBL5393965 | — | — | 1 | 5.59 |
| CHEMBL5439160 | — | — | 1 | 5.37 |
| CHEMBL5440718 | — | — | 1 | 5.34 |
| CHEMBL4594429 | AZD-1390 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423608 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5412393 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL5427147 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL5422058 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL5425498 | — | IC50 | = | 421.0 | nM | 6.38 |
| CHEMBL5412749 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL5408725 | — | IC50 | = | 449.0 | nM | 6.35 |
| CHEMBL5415921 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL2325697 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL5419225 | — | IC50 | = | 1641.0 | nM | 5.79 |
| CHEMBL5425941 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5393965 | — | IC50 | = | 2582.0 | nM | 5.59 |
| CHEMBL5439160 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5440718 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4594429 | AZD-1390 | IC50 | > | 30000.0 | nM | - |