Assay Detail
Functional
CHEMBL5332724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against ATM-deficient human SW620 cells assessed as reduction in cell viability incubated for 3 days by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.67 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423608 | — | — | 1 | 7.02 |
| CHEMBL5425498 | — | — | 1 | 6.84 |
| CHEMBL2325697 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423608 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5425498 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL2325697 | — | IC50 | = | 727.0 | nM | 6.14 |