Assay Detail
Functional
CHEMBL5332728
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against ATM-proficient human HT-29 cells assessed as reduction in cell viability incubated for 3 days in presence of AZD-1390 by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.40 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423608 | — | — | 1 | 7.72 |
| CHEMBL5425498 | — | — | 1 | 7.35 |
| CHEMBL2325697 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423608 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5425498 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2325697 | — | IC50 | = | 72.0 | nM | 7.14 |