Assay Detail
Functional
CHEMBL5332736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 3 days in presence of olaparib by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.28 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423608 | — | — | 1 | 6.48 |
| CHEMBL5425498 | — | — | 1 | 6.46 |
| CHEMBL2325697 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423608 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL5425498 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL2325697 | — | IC50 | = | 1221.0 | nM | 5.91 |