Assay Detail
Binding
CHEMBL5332749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NPP3 expressed in COS-7 cells using pNP-TMP as substrate preincubated for 10 mins followed by substrate addition and measured after 35 mins by microplate reader analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (CHEMBL5580) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of new adamantyl derivatives as promising antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.07 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4585698 | — | — | 1 | 6.59 |
| CHEMBL5432925 | — | — | 1 | 6.13 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.05 |
| CHEMBL5404116 | — | — | 1 | 5.52 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL117754 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4585698 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5432925 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL265502 | SURAMIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5404116 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | - | — | - | |
| CHEMBL117754 | — | IC50 | - | — | - |