Assay Detail
Binding
CHEMBL5333045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of G9a (unknown origin) using H3(1-20)-cys as substrate by HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT2 (CHEMBL6032) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of cysteine-targeting covalent histone methyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.80 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1231795 | — | — | 1 | 7.82 |
| CHEMBL569864 | — | — | 1 | 5.77 |
| CHEMBL2441082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1231795 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL569864 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2441082 | — | IC50 | < | 2.5 | nM | - |