Assay Detail
Functional
CHEMBL5333180
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.44 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407093 | — | — | 1 | 6.04 |
| CHEMBL5090109 | — | — | 1 | 5.62 |
| CHEMBL81925 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407093 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5090109 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL81925 | — | IC50 | = | 21520.0 | nM | 4.67 |