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Assay Detail

CHEMBL5333238

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani amastigotes infected in J774.A1 macrophage assessed as inhibition of parasite growth by luciferase assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Design and synthesis of novel halogen rich salicylanilides as potential antileishmanial agents.
Lal J, Ramalingam K, Meena R, Ansari SB, Saxena D, Chopra S, Goyal N, Reddy DN.
Eur J Med Chem (2023) 246 : 114996 -114996
PubMed 36565533 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 5.37 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2088012 1 5.68
CHEMBL3604894 1 5.58
CHEMBL2313091 1 5.54
CHEMBL1491305 1 5.49
CHEMBL2313089 1 5.46
CHEMBL589733 1 5.46
CHEMBL2313092 1 5.45
CHEMBL1448 NICLOSAMIDE 4.0 1 5.43
CHEMBL2179173 1 5.42
CHEMBL5438391 1 5.42
CHEMBL2088013 1 5.42
CHEMBL5421676 1 5.41
CHEMBL5427382 1 5.40
CHEMBL4553793 1 5.40
CHEMBL2313088 1 5.40
CHEMBL5410455 1 5.39
CHEMBL2088011 1 5.33
CHEMBL480300 1 5.13
CHEMBL5422300 1 5.13
CHEMBL2105450 OXYCLOZANIDE 2.0 1 5.11
CHEMBL459303 1 5.10
CHEMBL125 MILTEFOSINE 4.0 1 5.03
CHEMBL5179670 1 -
CHEMBL5413945 1 -
CHEMBL2348120 1 -
CHEMBL115523 N-PHENYLBENZAMIDE 1 -
CHEMBL3731970 1 -
CHEMBL5414742 1 -
CHEMBL2312822 1 -
CHEMBL5400714 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2088012 IC50 = 2090.0 nM 5.68
CHEMBL3604894 IC50 = 2620.0 nM 5.58
CHEMBL2313091 IC50 = 2890.0 nM 5.54
CHEMBL1491305 IC50 = 3270.0 nM 5.49
CHEMBL2313089 IC50 = 3500.0 nM 5.46
CHEMBL589733 IC50 = 3470.0 nM 5.46
CHEMBL2313092 IC50 = 3540.0 nM 5.45
CHEMBL1448 NICLOSAMIDE IC50 = 3680.0 nM 5.43
CHEMBL2179173 IC50 = 3830.0 nM 5.42
CHEMBL5438391 IC50 = 3820.0 nM 5.42
CHEMBL2088013 IC50 = 3830.0 nM 5.42
CHEMBL5421676 IC50 = 3880.0 nM 5.41
CHEMBL5427382 IC50 = 3950.0 nM 5.40
CHEMBL4553793 IC50 = 3980.0 nM 5.40
CHEMBL2313088 IC50 = 4000.0 nM 5.40
CHEMBL5410455 IC50 = 4060.0 nM 5.39
CHEMBL2088011 IC50 = 4620.0 nM 5.33
CHEMBL480300 IC50 = 7470.0 nM 5.13
CHEMBL5422300 IC50 = 7360.0 nM 5.13
CHEMBL2105450 OXYCLOZANIDE IC50 = 7710.0 nM 5.11
CHEMBL459303 IC50 = 7970.0 nM 5.10
CHEMBL125 MILTEFOSINE IC50 = 9250.0 nM 5.03
CHEMBL5179670 IC50 - -
CHEMBL5413945 IC50 - -
CHEMBL2348120 IC50 - -
CHEMBL115523 N-PHENYLBENZAMIDE IC50 - -
CHEMBL3731970 IC50 - -
CHEMBL5414742 IC50 - -
CHEMBL2312822 IC50 - -
CHEMBL5400714 IC50 - -
CHEMBL1892375 IC50 - -
CHEMBL82970 SALICYLANILIDE IC50 - -
CHEMBL5433530 IC50 - -