Assay Detail
Binding
CHEMBL5333475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at CRBN/BTK in human TMD8 cells assessed as induction of BTK degradation incubated for 24 hrs by immunoblotting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Tyrosine-protein kinase BTK (CHEMBL4523704) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
PROTACS: A technology with a gold rush-like atmosphere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414565 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414565 | — | EC50 | = | 4.0 | nM | 8.40 |