Assay Detail
Binding
CHEMBL5333577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MIF ketonase activity using phenylpyruvate as substrate
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage migration inhibitory factor (CHEMBL2085) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.60 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4160838 | — | — | 1 | 6.06 |
| CHEMBL250414 | — | — | 1 | 5.81 |
| CHEMBL5194716 | — | — | 1 | 5.69 |
| CHEMBL5414370 | — | — | 1 | 5.69 |
| CHEMBL5422812 | — | — | 1 | 5.67 |
| CHEMBL426432 | — | — | 1 | 5.52 |
| CHEMBL5394950 | — | — | 1 | 5.30 |
| CHEMBL5416169 | — | — | 1 | 5.06 |
| CHEMBL5406230 | — | — | 1 | 5.00 |
| CHEMBL126625 | — | — | 1 | 4.89 |
| CHEMBL5194043 | — | — | 1 | 4.71 |
| CHEMBL4756815 | — | — | 1 | 4.70 |
| CHEMBL5429570 | — | — | 1 | 4.66 |
| CHEMBL187150 | — | — | 1 | 4.62 |
| CHEMBL365686 | — | — | 1 | 4.59 |
| CHEMBL5434710 | — | — | 1 | 4.59 |
| CHEMBL5425801 | — | — | 1 | 4.53 |
| CHEMBL5420056 | — | — | 1 | 4.52 |
| CHEMBL5439791 | — | — | 1 | 4.50 |
| CHEMBL5184996 | — | — | 1 | 4.49 |
| CHEMBL5421404 | — | — | 1 | 4.48 |
| CHEMBL5420245 | — | — | 1 | 4.45 |
| CHEMBL5202256 | — | — | 1 | 4.41 |
| CHEMBL4168066 | — | — | 1 | 4.39 |
| CHEMBL2408880 | — | — | 1 | 4.37 |
| CHEMBL5428060 | — | — | 1 | 4.31 |
| CHEMBL5420295 | — | — | 1 | 4.31 |
| CHEMBL1965529 | — | — | 1 | 4.31 |
| CHEMBL2005135 | — | — | 1 | 4.29 |
| CHEMBL5430797 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4160838 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL250414 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5414370 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5194716 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL5422812 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL426432 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL5394950 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL5416169 | — | IC50 | = | 8750.0 | nM | 5.06 |
| CHEMBL5406230 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL126625 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5194043 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL4756815 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL5429570 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL187150 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL5434710 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL365686 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL5425801 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL5420056 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL5439791 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL5184996 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL5421404 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL5420245 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL5202256 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL4168066 | — | IC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL2408880 | — | IC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL5420295 | — | IC50 | = | 48900.0 | nM | 4.31 |
| CHEMBL1965529 | — | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL5428060 | — | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL2005135 | — | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL5430797 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL5433839 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL328217 | — | IC50 | = | 58800.0 | nM | 4.23 |
| CHEMBL5406331 | — | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL5412290 | — | IC50 | = | 63400.0 | nM | 4.20 |
| CHEMBL5423617 | — | IC50 | = | 64700.0 | nM | 4.19 |
| CHEMBL5419620 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL5439391 | — | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL5399015 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL5410035 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL5437688 | — | IC50 | = | 67200.0 | nM | 4.17 |
| CHEMBL5196134 | — | IC50 | = | 72600.0 | nM | 4.14 |
| CHEMBL5433973 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL4761197 | — | IC50 | = | 96500.0 | nM | 4.01 |
| CHEMBL5435908 | — | IC50 | = | 99300.0 | nM | 4.00 |
| CHEMBL5420420 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL5406276 | — | IC50 | - | — | - | |
| CHEMBL5419540 | — | IC50 | = | 204000.0 | nM | - |
| CHEMBL1383041 | — | IC50 | = | 127000.0 | nM | - |
| CHEMBL5400142 | — | IC50 | - | — | - |