Assay Detail
Functional
CHEMBL5333684
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against wild type HBV infected in human HepG2 cells assessed as inhibition of viral replication
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of N-sulfonylpiperidine-3-carboxamide derivatives as capsid assembly modulators inhibiting HBV in vitro and in HBV-transgenic mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.54 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428559 | — | — | 1 | 8.51 |
| CHEMBL713 | ENTECAVIR ANHYDROUS | 4.0 | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428559 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL713 | ENTECAVIR ANHYDROUS | EC50 | = | 270.0 | nM | 6.57 |