Assay Detail
Binding
CHEMBL5333750
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Inhibition of MAO-B (unknown origin) using kynuramine as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence based analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.83 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414700 | — | — | 1 | 7.85 |
| CHEMBL5415223 | — | — | 1 | 7.68 |
| CHEMBL5414652 | — | — | 1 | 7.48 |
| CHEMBL5398247 | — | — | 1 | 7.46 |
| CHEMBL5441072 | — | — | 1 | 7.31 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL5430381 | — | — | 1 | 7.24 |
| CHEMBL5427279 | — | — | 1 | 7.17 |
| CHEMBL5394801 | — | — | 1 | 7.07 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.03 |
| CHEMBL5400685 | — | — | 1 | 7.02 |
| CHEMBL5426461 | — | — | 1 | 6.60 |
| CHEMBL5418090 | — | — | 1 | 6.53 |
| CHEMBL5394462 | — | — | 1 | 6.48 |
| CHEMBL5403831 | — | — | 1 | 6.46 |
| CHEMBL5416185 | — | — | 1 | 6.44 |
| CHEMBL5438301 | — | — | 1 | 6.37 |
| CHEMBL5399743 | — | — | 1 | 6.36 |
| CHEMBL5428123 | — | — | 1 | 6.32 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.90 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414700 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5415223 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5414652 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5398247 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5441072 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5430381 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5427279 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5394801 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL887 | RASAGILINE | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5400685 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5426461 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL5418090 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL5394462 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL5403831 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL5416185 | — | IC50 | = | 366.0 | nM | 6.44 |
| CHEMBL5438301 | — | IC50 | = | 423.0 | nM | 6.37 |
| CHEMBL5399743 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL5428123 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 3760.0 | nM | 5.42 |