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Assay Detail

CHEMBL5333756

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of MAO-B (unknown origin) using kynuramine as substrate assessed as inhibition constant by Lineweaver-Burk plot analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease.
Cao Z, Fu X, Wang X, Zhang T, Zhong L, Xia Q, Zhu J.
Eur J Med Chem (2023) 249 : 115142 -115142
PubMed 36716641 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.75 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5414700 1 7.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5414700 Ki = 18.0 nM 7.75