Assay Detail
Binding
CHEMBL5333941
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of UppP in Escherichia coli using FPP as substrate pretreated for 20 mins followed by FPP addition and measured after 60 mins by malachite green based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Undecaprenyl-diphosphatase (CHEMBL4295581) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.57 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1087059 | — | — | 1 | 4.82 |
| CHEMBL5395162 | — | — | 1 | 4.80 |
| CHEMBL5432995 | — | — | 1 | 4.75 |
| CHEMBL3261880 | — | — | 1 | 4.68 |
| CHEMBL561057 | SQ109 | 2.0 | 1 | 4.50 |
| CHEMBL5403488 | — | — | 1 | 4.43 |
| CHEMBL3261881 | — | — | 1 | 4.04 |
| CHEMBL5414003 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1087059 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5395162 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5432995 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3261880 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL561057 | SQ109 | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5403488 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3261881 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL5414003 | — | IC50 | = | 153000.0 | nM | - |