Assay Detail
Binding
CHEMBL5334253
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Inhibition of sEH (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Characterization of a Potent Soluble Epoxide Hydrolase Inhibitor for the Treatment of Acute Pancreatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.75 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244405 | — | — | 1 | 9.30 |
| CHEMBL436774 | AR9281 | 2.0 | 1 | 8.10 |
| CHEMBL4590950 | — | — | 1 | 7.21 |
| CHEMBL215387 | — | — | 1 | 7.16 |
| CHEMBL4449485 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244405 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL436774 | AR9281 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4590950 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL215387 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4449485 | — | IC50 | = | 100.0 | nM | 7.00 |