Assay Detail
Functional
CHEMBL5334338
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum D6 infected in human red blood cells incubated for 24 hrs followed by hypoxanthine addition and measured after 18 hrs by [3H]-hypoxanthine incorporation based liquid scintillation counter analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Basic Nitrogen (BaN) Is a Key Property of Antimalarial Chemical Space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.24 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253715 | — | — | 1 | 7.50 |
| CHEMBL253716 | — | — | 1 | 7.47 |
| CHEMBL253508 | — | — | 1 | 7.34 |
| CHEMBL119096 | CRYPTOLEPINE | — | 1 | 6.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253715 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL253716 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL253508 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL119096 | CRYPTOLEPINE | IC50 | = | 222.0 | nM | 6.65 |