Assay Detail
Functional
CHEMBL5334343
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Antiplasmodial activity against Plasmodium falciparum 3D7
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Basic Nitrogen (BaN) Is a Key Property of Antimalarial Chemical Space.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.27 | 8.05 |
| IC50 | 3 | 6.95 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636879 | — | — | 1 | 8.05 |
| CHEMBL4633246 | — | — | 1 | 7.85 |
| CHEMBL2029589 | — | — | 1 | 7.66 |
| CHEMBL2029587 | — | — | 1 | 7.60 |
| CHEMBL4643370 | — | — | 1 | 7.44 |
| CHEMBL4642145 | — | — | 1 | 7.21 |
| CHEMBL600689 | — | — | 1 | 6.64 |
| CHEMBL4636244 | — | — | 1 | 6.41 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636879 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4633246 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2029589 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2029587 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4643370 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4642145 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL600689 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4636244 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 2654.0 | nM | 5.58 |