Assay Detail
Binding
CHEMBL5334385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to full length PHD2 (181 to 426 residues) (unknown origin) by fluorescence polarization assay
31
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.25 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175552 | — | — | 1 | 7.88 |
| CHEMBL4162752 | DDO-3055 | 1.0 | 1 | 7.81 |
| CHEMBL5436949 | — | — | 1 | 7.71 |
| CHEMBL5394158 | — | — | 1 | 7.65 |
| CHEMBL4126434 | — | — | 1 | 7.64 |
| CHEMBL5420139 | — | — | 1 | 7.61 |
| CHEMBL5419909 | — | — | 1 | 7.61 |
| CHEMBL5421805 | — | — | 1 | 7.49 |
| CHEMBL5434005 | — | — | 1 | 7.46 |
| CHEMBL5437125 | — | — | 1 | 7.46 |
| CHEMBL5399097 | — | — | 1 | 7.40 |
| CHEMBL5404669 | — | — | 1 | 7.36 |
| CHEMBL5397478 | — | — | 2 | 7.35 |
| CHEMBL5433080 | — | — | 1 | 7.27 |
| CHEMBL5419325 | — | — | 1 | 7.25 |
| CHEMBL5403753 | — | — | 1 | 7.24 |
| CHEMBL5419740 | — | — | 1 | 7.19 |
| CHEMBL5405247 | — | — | 1 | 7.17 |
| CHEMBL5405997 | — | — | 1 | 7.16 |
| CHEMBL5414229 | — | — | 1 | 7.12 |
| CHEMBL5398964 | — | — | 1 | 7.11 |
| CHEMBL5411765 | — | — | 1 | 7.03 |
| CHEMBL5437473 | — | — | 1 | 7.00 |
| CHEMBL2338329 | ROXADUSTAT | 4.0 | 1 | 6.93 |
| CHEMBL5410556 | — | — | 1 | 6.88 |
| CHEMBL5404727 | — | — | 1 | 6.84 |
| CHEMBL5398272 | — | — | 1 | 6.80 |
| CHEMBL5420134 | — | — | 1 | 6.71 |
| CHEMBL3646221 | VADADUSTAT | 4.0 | 1 | 6.59 |
| CHEMBL5435363 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175552 | — | IC50 | = | 13.07 | nM | 7.88 |
| CHEMBL4162752 | DDO-3055 | IC50 | = | 15.62 | nM | 7.81 |
| CHEMBL5436949 | — | IC50 | = | 19.62 | nM | 7.71 |
| CHEMBL5394158 | — | IC50 | = | 22.53 | nM | 7.65 |
| CHEMBL4126434 | — | IC50 | = | 22.73 | nM | 7.64 |
| CHEMBL5420139 | — | IC50 | = | 24.63 | nM | 7.61 |
| CHEMBL5419909 | — | IC50 | = | 24.32 | nM | 7.61 |
| CHEMBL5421805 | — | IC50 | = | 32.45 | nM | 7.49 |
| CHEMBL5434005 | — | IC50 | = | 34.45 | nM | 7.46 |
| CHEMBL5437125 | — | IC50 | = | 34.58 | nM | 7.46 |
| CHEMBL5399097 | — | IC50 | = | 39.93 | nM | 7.40 |
| CHEMBL5404669 | — | IC50 | = | 43.42 | nM | 7.36 |
| CHEMBL5397478 | — | IC50 | = | 44.25 | nM | 7.35 |
| CHEMBL5397478 | — | IC50 | = | 44.25 | nM | 7.35 |
| CHEMBL5433080 | — | IC50 | = | 54.08 | nM | 7.27 |
| CHEMBL5419325 | — | IC50 | = | 56.79 | nM | 7.25 |
| CHEMBL5403753 | — | IC50 | = | 57.65 | nM | 7.24 |
| CHEMBL5419740 | — | IC50 | = | 64.54 | nM | 7.19 |
| CHEMBL5405247 | — | IC50 | = | 67.45 | nM | 7.17 |
| CHEMBL5405997 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL5414229 | — | IC50 | = | 76.48 | nM | 7.12 |
| CHEMBL5398964 | — | IC50 | = | 77.09 | nM | 7.11 |
| CHEMBL5411765 | — | IC50 | = | 92.72 | nM | 7.03 |
| CHEMBL5437473 | — | IC50 | = | 98.9 | nM | 7.00 |
| CHEMBL2338329 | ROXADUSTAT | IC50 | = | 117.2 | nM | 6.93 |
| CHEMBL5410556 | — | IC50 | = | 130.8 | nM | 6.88 |
| CHEMBL5404727 | — | IC50 | = | 143.8 | nM | 6.84 |
| CHEMBL5398272 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL5420134 | — | IC50 | = | 194.9 | nM | 6.71 |
| CHEMBL3646221 | VADADUSTAT | IC50 | = | 256.9 | nM | 6.59 |
| CHEMBL5435363 | — | IC50 | = | 256.5 | nM | 6.59 |