Assay Detail
Functional
CHEMBL5334579
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Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 786-0 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.48 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410547 | — | — | 1 | 4.91 |
| CHEMBL5399186 | — | — | 1 | 4.62 |
| CHEMBL5409497 | — | — | 1 | 4.57 |
| CHEMBL5399626 | — | — | 1 | 4.57 |
| CHEMBL5396926 | — | — | 1 | 4.55 |
| CHEMBL5408813 | — | — | 1 | 4.54 |
| CHEMBL5417852 | — | — | 1 | 4.53 |
| CHEMBL5413342 | — | — | 1 | 4.53 |
| CHEMBL5432376 | — | — | 1 | 4.52 |
| CHEMBL5438200 | — | — | 1 | 4.52 |
| CHEMBL5399396 | — | — | 1 | 4.51 |
| CHEMBL5439875 | — | — | 1 | 4.47 |
| CHEMBL5398542 | — | — | 1 | 4.47 |
| CHEMBL5430906 | — | — | 1 | 4.46 |
| CHEMBL5394804 | — | — | 1 | 4.45 |
| CHEMBL5435072 | — | — | 1 | 4.45 |
| CHEMBL5438260 | — | — | 1 | 4.44 |
| CHEMBL5399779 | — | — | 1 | 4.39 |
| CHEMBL5435634 | — | — | 1 | 4.39 |
| CHEMBL5420694 | — | — | 1 | 4.36 |
| CHEMBL5425342 | — | — | 1 | 4.36 |
| CHEMBL5413578 | — | — | 1 | 4.19 |
| CHEMBL5405420 | — | — | 1 | 4.15 |
| CHEMBL1257030 | LONIDAMINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410547 | — | IC50 | = | 12210.0 | nM | 4.91 |
| CHEMBL5399186 | — | IC50 | = | 23880.0 | nM | 4.62 |
| CHEMBL5409497 | — | IC50 | = | 26890.0 | nM | 4.57 |
| CHEMBL5399626 | — | IC50 | = | 27110.0 | nM | 4.57 |
| CHEMBL5396926 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL5408813 | — | IC50 | = | 29180.0 | nM | 4.54 |
| CHEMBL5417852 | — | IC50 | = | 29370.0 | nM | 4.53 |
| CHEMBL5413342 | — | IC50 | = | 29810.0 | nM | 4.53 |
| CHEMBL5432376 | — | IC50 | = | 30280.0 | nM | 4.52 |
| CHEMBL5438200 | — | IC50 | = | 30090.0 | nM | 4.52 |
| CHEMBL5399396 | — | IC50 | = | 30790.0 | nM | 4.51 |
| CHEMBL5439875 | — | IC50 | = | 33890.0 | nM | 4.47 |
| CHEMBL5398542 | — | IC50 | = | 34070.0 | nM | 4.47 |
| CHEMBL5430906 | — | IC50 | = | 34930.0 | nM | 4.46 |
| CHEMBL5394804 | — | IC50 | = | 35860.0 | nM | 4.45 |
| CHEMBL5435072 | — | IC50 | = | 35770.0 | nM | 4.45 |
| CHEMBL5438260 | — | IC50 | = | 36680.0 | nM | 4.44 |
| CHEMBL5399779 | — | IC50 | = | 40920.0 | nM | 4.39 |
| CHEMBL5435634 | — | IC50 | = | 40420.0 | nM | 4.39 |
| CHEMBL5420694 | — | IC50 | = | 43740.0 | nM | 4.36 |
| CHEMBL5425342 | — | IC50 | = | 43290.0 | nM | 4.36 |
| CHEMBL5413578 | — | IC50 | = | 63940.0 | nM | 4.19 |
| CHEMBL5405420 | — | IC50 | = | 70270.0 | nM | 4.15 |
| CHEMBL1257030 | LONIDAMINE | IC50 | = | 120430.0 | nM | - |