Assay Detail
Functional
CHEMBL5334580
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Antiproliferative activity against mouse 4T1 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | 4T1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.54 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398542 | — | — | 1 | 5.29 |
| CHEMBL5408813 | — | — | 1 | 4.76 |
| CHEMBL5438200 | — | — | 1 | 4.64 |
| CHEMBL5399186 | — | — | 1 | 4.63 |
| CHEMBL5394804 | — | — | 1 | 4.62 |
| CHEMBL5435072 | — | — | 1 | 4.61 |
| CHEMBL5399779 | — | — | 1 | 4.58 |
| CHEMBL5396926 | — | — | 1 | 4.56 |
| CHEMBL5439875 | — | — | 1 | 4.55 |
| CHEMBL5420694 | — | — | 1 | 4.54 |
| CHEMBL5413578 | — | — | 1 | 4.51 |
| CHEMBL5413342 | — | — | 1 | 4.50 |
| CHEMBL5435634 | — | — | 1 | 4.49 |
| CHEMBL5405420 | — | — | 1 | 4.49 |
| CHEMBL5409497 | — | — | 1 | 4.48 |
| CHEMBL5399396 | — | — | 1 | 4.47 |
| CHEMBL5430906 | — | — | 1 | 4.46 |
| CHEMBL5410547 | — | — | 1 | 4.46 |
| CHEMBL5399626 | — | — | 1 | 4.46 |
| CHEMBL5417852 | — | — | 1 | 4.44 |
| CHEMBL5425342 | — | — | 1 | 4.40 |
| CHEMBL5438260 | — | — | 1 | 4.37 |
| CHEMBL5432376 | — | — | 1 | 4.14 |
| CHEMBL1257030 | LONIDAMINE | 3.0 | 1 | - |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398542 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL5408813 | — | IC50 | = | 17210.0 | nM | 4.76 |
| CHEMBL5438200 | — | IC50 | = | 22850.0 | nM | 4.64 |
| CHEMBL5399186 | — | IC50 | = | 23460.0 | nM | 4.63 |
| CHEMBL5394804 | — | IC50 | = | 24180.0 | nM | 4.62 |
| CHEMBL5435072 | — | IC50 | = | 24690.0 | nM | 4.61 |
| CHEMBL5399779 | — | IC50 | = | 26310.0 | nM | 4.58 |
| CHEMBL5396926 | — | IC50 | = | 27560.0 | nM | 4.56 |
| CHEMBL5439875 | — | IC50 | = | 28290.0 | nM | 4.55 |
| CHEMBL5420694 | — | IC50 | = | 28880.0 | nM | 4.54 |
| CHEMBL5413578 | — | IC50 | = | 31170.0 | nM | 4.51 |
| CHEMBL5413342 | — | IC50 | = | 31570.0 | nM | 4.50 |
| CHEMBL5435634 | — | IC50 | = | 32580.0 | nM | 4.49 |
| CHEMBL5405420 | — | IC50 | = | 32240.0 | nM | 4.49 |
| CHEMBL5409497 | — | IC50 | = | 33060.0 | nM | 4.48 |
| CHEMBL5399396 | — | IC50 | = | 34160.0 | nM | 4.47 |
| CHEMBL5430906 | — | IC50 | = | 34370.0 | nM | 4.46 |
| CHEMBL5410547 | — | IC50 | = | 34650.0 | nM | 4.46 |
| CHEMBL5399626 | — | IC50 | = | 34480.0 | nM | 4.46 |
| CHEMBL5417852 | — | IC50 | = | 36560.0 | nM | 4.44 |
| CHEMBL5425342 | — | IC50 | = | 40090.0 | nM | 4.40 |
| CHEMBL5438260 | — | IC50 | = | 42320.0 | nM | 4.37 |
| CHEMBL5432376 | — | IC50 | = | 71790.0 | nM | 4.14 |
| CHEMBL1257030 | LONIDAMINE | IC50 | = | 152900.0 | nM | - |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 176110.0 | nM | - |