Assay Detail
Functional
CHEMBL5334581
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Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PANC-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.39 | 4.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410547 | — | — | 1 | 4.59 |
| CHEMBL5413342 | — | — | 1 | 4.57 |
| CHEMBL5398542 | — | — | 1 | 4.50 |
| CHEMBL5399626 | — | — | 1 | 4.43 |
| CHEMBL5399396 | — | — | 1 | 4.42 |
| CHEMBL5438200 | — | — | 1 | 4.42 |
| CHEMBL5432376 | — | — | 1 | 4.42 |
| CHEMBL5425342 | — | — | 1 | 4.41 |
| CHEMBL5435072 | — | — | 1 | 4.41 |
| CHEMBL5399779 | — | — | 1 | 4.40 |
| CHEMBL5439875 | — | — | 1 | 4.40 |
| CHEMBL5435634 | — | — | 1 | 4.36 |
| CHEMBL5420694 | — | — | 1 | 4.34 |
| CHEMBL5438260 | — | — | 1 | 4.34 |
| CHEMBL5399186 | — | — | 1 | 4.34 |
| CHEMBL5405420 | — | — | 1 | 4.33 |
| CHEMBL5409497 | — | — | 1 | 4.32 |
| CHEMBL5430906 | — | — | 1 | 4.31 |
| CHEMBL5417852 | — | — | 1 | 4.30 |
| CHEMBL5408813 | — | — | 1 | 4.28 |
| CHEMBL5413578 | — | — | 1 | 4.28 |
| CHEMBL1257030 | LONIDAMINE | 3.0 | 1 | - |
| CHEMBL5394804 | — | — | 1 | - |
| CHEMBL5396926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410547 | — | IC50 | = | 25430.0 | nM | 4.59 |
| CHEMBL5413342 | — | IC50 | = | 26710.0 | nM | 4.57 |
| CHEMBL5398542 | — | IC50 | = | 31530.0 | nM | 4.50 |
| CHEMBL5399626 | — | IC50 | = | 37340.0 | nM | 4.43 |
| CHEMBL5399396 | — | IC50 | = | 38260.0 | nM | 4.42 |
| CHEMBL5438200 | — | IC50 | = | 37780.0 | nM | 4.42 |
| CHEMBL5432376 | — | IC50 | = | 37770.0 | nM | 4.42 |
| CHEMBL5425342 | — | IC50 | = | 39110.0 | nM | 4.41 |
| CHEMBL5435072 | — | IC50 | = | 38580.0 | nM | 4.41 |
| CHEMBL5399779 | — | IC50 | = | 40150.0 | nM | 4.40 |
| CHEMBL5439875 | — | IC50 | = | 39520.0 | nM | 4.40 |
| CHEMBL5435634 | — | IC50 | = | 43980.0 | nM | 4.36 |
| CHEMBL5420694 | — | IC50 | = | 46120.0 | nM | 4.34 |
| CHEMBL5438260 | — | IC50 | = | 45610.0 | nM | 4.34 |
| CHEMBL5399186 | — | IC50 | = | 45310.0 | nM | 4.34 |
| CHEMBL5405420 | — | IC50 | = | 46320.0 | nM | 4.33 |
| CHEMBL5409497 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL5430906 | — | IC50 | = | 49160.0 | nM | 4.31 |
| CHEMBL5417852 | — | IC50 | = | 49850.0 | nM | 4.30 |
| CHEMBL5408813 | — | IC50 | = | 53040.0 | nM | 4.28 |
| CHEMBL5413578 | — | IC50 | = | 53020.0 | nM | 4.28 |
| CHEMBL1257030 | LONIDAMINE | IC50 | = | 164510.0 | nM | - |
| CHEMBL5394804 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5396926 | — | IC50 | > | 100000.0 | nM | - |