Assay Detail
Functional
CHEMBL5334582
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Antiproliferative activity against human HGC-27 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.81 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5398542 | — | — | 1 | 5.21 |
| CHEMBL5410547 | — | — | 1 | 5.14 |
| CHEMBL5432376 | — | — | 1 | 5.12 |
| CHEMBL5396926 | — | — | 1 | 5.11 |
| CHEMBL5438260 | — | — | 1 | 5.01 |
| CHEMBL5399626 | — | — | 1 | 4.99 |
| CHEMBL5405420 | — | — | 1 | 4.99 |
| CHEMBL5430906 | — | — | 1 | 4.92 |
| CHEMBL5413342 | — | — | 1 | 4.90 |
| CHEMBL5409497 | — | — | 1 | 4.89 |
| CHEMBL5408813 | — | — | 1 | 4.86 |
| CHEMBL5399396 | — | — | 1 | 4.78 |
| CHEMBL5417852 | — | — | 1 | 4.78 |
| CHEMBL5435072 | — | — | 1 | 4.74 |
| CHEMBL5394804 | — | — | 1 | 4.73 |
| CHEMBL5399779 | — | — | 1 | 4.72 |
| CHEMBL5420694 | — | — | 1 | 4.72 |
| CHEMBL5413578 | — | — | 1 | 4.68 |
| CHEMBL5439875 | — | — | 1 | 4.67 |
| CHEMBL5425342 | — | — | 1 | 4.66 |
| CHEMBL5435634 | — | — | 1 | 4.64 |
| CHEMBL5438200 | — | — | 1 | 4.62 |
| CHEMBL5399186 | — | — | 1 | 4.54 |
| CHEMBL1257030 | LONIDAMINE | 3.0 | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5398542 | — | IC50 | = | 6110.0 | nM | 5.21 |
| CHEMBL5410547 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL5432376 | — | IC50 | = | 7570.0 | nM | 5.12 |
| CHEMBL5396926 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL5438260 | — | IC50 | = | 9730.0 | nM | 5.01 |
| CHEMBL5399626 | — | IC50 | = | 10250.0 | nM | 4.99 |
| CHEMBL5405420 | — | IC50 | = | 10250.0 | nM | 4.99 |
| CHEMBL5430906 | — | IC50 | = | 12020.0 | nM | 4.92 |
| CHEMBL5413342 | — | IC50 | = | 12520.0 | nM | 4.90 |
| CHEMBL5409497 | — | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL5408813 | — | IC50 | = | 13750.0 | nM | 4.86 |
| CHEMBL5399396 | — | IC50 | = | 16590.0 | nM | 4.78 |
| CHEMBL5417852 | — | IC50 | = | 16490.0 | nM | 4.78 |
| CHEMBL5435072 | — | IC50 | = | 18320.0 | nM | 4.74 |
| CHEMBL5394804 | — | IC50 | = | 18670.0 | nM | 4.73 |
| CHEMBL5399779 | — | IC50 | = | 19090.0 | nM | 4.72 |
| CHEMBL5420694 | — | IC50 | = | 19160.0 | nM | 4.72 |
| CHEMBL5413578 | — | IC50 | = | 20970.0 | nM | 4.68 |
| CHEMBL5439875 | — | IC50 | = | 21120.0 | nM | 4.67 |
| CHEMBL5425342 | — | IC50 | = | 21880.0 | nM | 4.66 |
| CHEMBL5435634 | — | IC50 | = | 23060.0 | nM | 4.64 |
| CHEMBL5438200 | — | IC50 | = | 24030.0 | nM | 4.62 |
| CHEMBL5399186 | — | IC50 | = | 28616.0 | nM | 4.54 |
| CHEMBL1257030 | LONIDAMINE | IC50 | = | 77620.0 | nM | 4.11 |