Assay Detail
Functional
CHEMBL5334583
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured for 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.46 | 4.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438200 | — | — | 1 | 4.74 |
| CHEMBL5435634 | — | — | 1 | 4.73 |
| CHEMBL5410547 | — | — | 1 | 4.73 |
| CHEMBL5399186 | — | — | 1 | 4.72 |
| CHEMBL5398542 | — | — | 1 | 4.67 |
| CHEMBL5399396 | — | — | 1 | 4.62 |
| CHEMBL5413578 | — | — | 1 | 4.55 |
| CHEMBL5413342 | — | — | 1 | 4.51 |
| CHEMBL5439875 | — | — | 1 | 4.49 |
| CHEMBL5408813 | — | — | 1 | 4.48 |
| CHEMBL5430906 | — | — | 1 | 4.47 |
| CHEMBL5432376 | — | — | 1 | 4.44 |
| CHEMBL5396926 | — | — | 1 | 4.44 |
| CHEMBL5425342 | — | — | 1 | 4.42 |
| CHEMBL5417852 | — | — | 1 | 4.38 |
| CHEMBL5420694 | — | — | 1 | 4.34 |
| CHEMBL5405420 | — | — | 1 | 4.19 |
| CHEMBL5399779 | — | — | 1 | 4.19 |
| CHEMBL5399626 | — | — | 1 | 4.19 |
| CHEMBL5394804 | — | — | 1 | 4.19 |
| CHEMBL5435072 | — | — | 1 | 4.18 |
| CHEMBL1257030 | LONIDAMINE | 3.0 | 1 | - |
| CHEMBL5438260 | — | — | 1 | - |
| CHEMBL5409497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438200 | — | IC50 | = | 18160.0 | nM | 4.74 |
| CHEMBL5435634 | — | IC50 | = | 18780.0 | nM | 4.73 |
| CHEMBL5410547 | — | IC50 | = | 18740.0 | nM | 4.73 |
| CHEMBL5399186 | — | IC50 | = | 18920.0 | nM | 4.72 |
| CHEMBL5398542 | — | IC50 | = | 21650.0 | nM | 4.67 |
| CHEMBL5399396 | — | IC50 | = | 23880.0 | nM | 4.62 |
| CHEMBL5413578 | — | IC50 | = | 28340.0 | nM | 4.55 |
| CHEMBL5413342 | — | IC50 | = | 31220.0 | nM | 4.51 |
| CHEMBL5439875 | — | IC50 | = | 32530.0 | nM | 4.49 |
| CHEMBL5408813 | — | IC50 | = | 33140.0 | nM | 4.48 |
| CHEMBL5430906 | — | IC50 | = | 33880.0 | nM | 4.47 |
| CHEMBL5432376 | — | IC50 | = | 36330.0 | nM | 4.44 |
| CHEMBL5396926 | — | IC50 | = | 35940.0 | nM | 4.44 |
| CHEMBL5425342 | — | IC50 | = | 37660.0 | nM | 4.42 |
| CHEMBL5417852 | — | IC50 | = | 42020.0 | nM | 4.38 |
| CHEMBL5420694 | — | IC50 | = | 45470.0 | nM | 4.34 |
| CHEMBL5405420 | — | IC50 | = | 64210.0 | nM | 4.19 |
| CHEMBL5399779 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL5399626 | — | IC50 | = | 64780.0 | nM | 4.19 |
| CHEMBL5394804 | — | IC50 | = | 65060.0 | nM | 4.19 |
| CHEMBL5435072 | — | IC50 | = | 66750.0 | nM | 4.18 |
| CHEMBL1257030 | LONIDAMINE | IC50 | = | 197450.0 | nM | - |
| CHEMBL5438260 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5409497 | — | IC50 | > | 100000.0 | nM | - |