Assay Detail
Binding
CHEMBL5334700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from postmortem human brain membrane homogenate 5-HT2A receptor incubated for 120 mins by microbeta liquid scintillation counter analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, Molecular Docking, and Biological Evaluation of Novel Pimavanserin-Based Analogues as Potential Serotonin 5-HT<sub>2A</sub> Receptor Inverse Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.30 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414859 | — | — | 1 | 10.30 |
| CHEMBL2111101 | PIMAVANSERIN | 4.0 | 1 | 9.30 |
| CHEMBL5414080 | — | — | 1 | 9.30 |
| CHEMBL5403965 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414859 | — | Ki | = | 0.05012 | nM | 10.30 |
| CHEMBL2111101 | PIMAVANSERIN | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL5414080 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL5403965 | — | Ki | = | 5.012 | nM | 8.30 |