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Assay Detail

CHEMBL5335037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against DENV-2 16681 expressing eGFP infected in african green monkey Vero cells incubated with cells for 24 hrs followed by viral infection measured after 3 days by laser microscopic analysis
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 2
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

dengue virus type 2 (CHEMBL613966)
Type ORGANISM
Organism dengue virus type 2

Publication

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors.
Kesteleyn B, Bardiot D, Bonfanti JF, De Boeck B, Goethals O, Kaptein SJF, Stoops B, Coesemans E, Fortin J, Muller P, Doublet F, Carlens G, Koukni M, Smets W, Raboisson P, Chaltin P, Simmen K, Van Loock M, Neyts J, Marchand A, Jonckers THM.
J Med Chem (2023) 66 : 8808 -8821
PubMed 37389813 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 8.17 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5417174 1 9.00
CHEMBL5417083 1 9.00
CHEMBL5430694 1 9.00
CHEMBL5409462 1 8.70
CHEMBL5420204 1 8.70
CHEMBL5399054 1 8.52
CHEMBL5405145 1 8.52
CHEMBL5430778 1 8.52
CHEMBL5401580 1 8.40
CHEMBL5406259 1 8.30
CHEMBL5412185 1 8.30
CHEMBL5438964 1 8.22
CHEMBL5437825 1 8.05
CHEMBL5400299 3 7.96
CHEMBL5397123 1 7.80
CHEMBL5437466 1 7.39
CHEMBL4203293 1 7.31
CHEMBL5424068 1 6.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5417174 EC50 = 1.0 nM 9.00
CHEMBL5417083 EC50 = 1.0 nM 9.00
CHEMBL5430694 EC50 = 1.0 nM 9.00
CHEMBL5409462 EC50 = 2.0 nM 8.70
CHEMBL5420204 EC50 = 2.0 nM 8.70
CHEMBL5405145 EC50 = 3.0 nM 8.52
CHEMBL5430778 EC50 = 3.0 nM 8.52
CHEMBL5399054 EC50 = 3.0 nM 8.52
CHEMBL5401580 EC50 = 4.0 nM 8.40
CHEMBL5412185 EC50 = 5.0 nM 8.30
CHEMBL5406259 EC50 = 5.0 nM 8.30
CHEMBL5438964 EC50 = 6.0 nM 8.22
CHEMBL5437825 EC50 = 9.0 nM 8.05
CHEMBL5400299 EC50 = 11.0 nM 7.96
CHEMBL5400299 EC50 = 15.0 nM 7.82
CHEMBL5397123 EC50 = 16.0 nM 7.80
CHEMBL5437466 EC50 = 41.0 nM 7.39
CHEMBL4203293 EC50 = 49.0 nM 7.31
CHEMBL5400299 EC50 = 93.0 nM 7.03
CHEMBL5424068 EC50 = 170.0 nM 6.77