Assay Detail
Binding
CHEMBL5335368
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Displacement of [3H]N-methylspiperone from human dopamine D2 receptor assessed as inhibition constant
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.03 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.02 |
| CHEMBL5425375 | — | — | 1 | 6.23 |
| CHEMBL5396616 | — | — | 1 | 6.21 |
| CHEMBL5438487 | — | — | 1 | 6.09 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 6.01 |
| CHEMBL5399568 | — | — | 1 | 5.84 |
| CHEMBL5410716 | — | — | 1 | 5.83 |
| CHEMBL5433001 | — | — | 1 | 5.68 |
| CHEMBL5410387 | — | — | 1 | 5.57 |
| CHEMBL5399166 | — | — | 1 | 5.56 |
| CHEMBL5428803 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL5425375 | — | Ki | = | 591.0 | nM | 6.23 |
| CHEMBL5396616 | — | Ki | = | 616.0 | nM | 6.21 |
| CHEMBL5438487 | — | Ki | = | 811.0 | nM | 6.09 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 974.0 | nM | 6.01 |
| CHEMBL5399568 | — | Ki | = | 1433.0 | nM | 5.84 |
| CHEMBL5410716 | — | Ki | = | 1491.0 | nM | 5.83 |
| CHEMBL5433001 | — | Ki | = | 2089.0 | nM | 5.68 |
| CHEMBL5410387 | — | Ki | = | 2682.0 | nM | 5.57 |
| CHEMBL5399166 | — | Ki | = | 2739.0 | nM | 5.56 |
| CHEMBL5428803 | — | Ki | = | 5045.0 | nM | 5.30 |