Assay Detail
Binding
CHEMBL5335369
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Displacement of [3H]N-methylspiperone from human dopamine D3 receptor assessed as inhibition constant
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Selective Dopamine Receptor Ligands Derived from (-)-Stepholidine via C-3 Alkoxylation and C-3/C-9 Dialkoxylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.66 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.96 |
| CHEMBL5410716 | — | — | 1 | 7.58 |
| CHEMBL487387 | STEPHOLIDINE | — | 1 | 7.52 |
| CHEMBL5399568 | — | — | 1 | 7.48 |
| CHEMBL5433001 | — | — | 1 | 7.40 |
| CHEMBL5410387 | — | — | 1 | 7.34 |
| CHEMBL5399166 | — | — | 1 | 7.29 |
| CHEMBL5429932 | — | — | 1 | 7.18 |
| CHEMBL5428803 | — | — | 1 | 7.07 |
| CHEMBL5439212 | — | — | 1 | 7.05 |
| CHEMBL5396616 | — | — | 1 | 6.58 |
| CHEMBL5399422 | — | — | 1 | 6.57 |
| CHEMBL5437148 | — | — | 1 | 6.56 |
| CHEMBL5420387 | — | — | 1 | 6.38 |
| CHEMBL5414499 | — | — | 1 | 6.28 |
| CHEMBL5399933 | — | — | 1 | 6.26 |
| CHEMBL5435602 | — | — | 1 | 6.24 |
| CHEMBL5394838 | — | — | 1 | 6.12 |
| CHEMBL5402269 | — | — | 1 | 6.05 |
| CHEMBL5409939 | — | — | 1 | 6.03 |
| CHEMBL5425375 | — | — | 1 | 5.98 |
| CHEMBL5395272 | — | — | 1 | 5.73 |
| CHEMBL5420515 | — | — | 1 | 5.67 |
| CHEMBL5438487 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5410716 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL487387 | STEPHOLIDINE | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5399568 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL5433001 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5410387 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL5399166 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL5429932 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL5428803 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL5439212 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL5396616 | — | Ki | = | 262.0 | nM | 6.58 |
| CHEMBL5399422 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL5437148 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL5420387 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL5414499 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL5399933 | — | Ki | = | 551.0 | nM | 6.26 |
| CHEMBL5435602 | — | Ki | = | 576.0 | nM | 6.24 |
| CHEMBL5394838 | — | Ki | = | 753.0 | nM | 6.12 |
| CHEMBL5402269 | — | Ki | = | 898.0 | nM | 6.05 |
| CHEMBL5409939 | — | Ki | = | 929.0 | nM | 6.03 |
| CHEMBL5425375 | — | Ki | = | 1045.0 | nM | 5.98 |
| CHEMBL5395272 | — | Ki | = | 1852.0 | nM | 5.73 |
| CHEMBL5420515 | — | Ki | = | 2131.0 | nM | 5.67 |
| CHEMBL5438487 | — | Ki | = | 2618.0 | nM | 5.58 |