Assay Detail
Functional
CHEMBL5336080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell viability at 72 hrs by SRB assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 7.45 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421145 | — | — | 1 | 9.35 |
| CHEMBL5431155 | — | — | 1 | 8.77 |
| CHEMBL5413890 | — | — | 1 | 8.68 |
| CHEMBL5439639 | — | — | 1 | 8.65 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 8.62 |
| CHEMBL5416318 | — | — | 1 | 8.55 |
| CHEMBL5417778 | — | — | 1 | 8.52 |
| CHEMBL5433246 | — | — | 1 | 8.52 |
| CHEMBL5418853 | — | — | 1 | 8.35 |
| CHEMBL5409679 | — | — | 1 | 8.20 |
| CHEMBL5396894 | — | — | 1 | 7.79 |
| CHEMBL5441013 | — | — | 1 | 7.79 |
| CHEMBL5422822 | — | — | 1 | 7.59 |
| CHEMBL5404900 | — | — | 1 | 7.09 |
| CHEMBL5417356 | — | — | 1 | 6.95 |
| CHEMBL5395817 | — | — | 1 | 6.82 |
| CHEMBL5406214 | — | — | 1 | 6.75 |
| CHEMBL5398480 | — | — | 1 | 6.31 |
| CHEMBL5436416 | — | — | 1 | 6.26 |
| CHEMBL5406147 | — | — | 1 | 6.22 |
| CHEMBL5407780 | — | — | 1 | 6.14 |
| CHEMBL5420377 | — | — | 1 | 6.13 |
| CHEMBL5408329 | — | — | 1 | 6.07 |
| CHEMBL5403629 | — | — | 1 | 6.07 |
| CHEMBL5424286 | — | — | 1 | 6.00 |
| CHEMBL5407079 | — | — | 1 | - |
| CHEMBL5413228 | — | — | 1 | - |
| CHEMBL5440228 | — | — | 1 | - |
| CHEMBL5420266 | — | — | 1 | - |
| CHEMBL5405758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421145 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5431155 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5413890 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL5439639 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5416318 | — | IC50 | = | 2.81 | nM | 8.55 |
| CHEMBL5417778 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5433246 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5418853 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5409679 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5396894 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL5441013 | — | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL5422822 | — | IC50 | = | 25.8 | nM | 7.59 |
| CHEMBL5404900 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5417356 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL5395817 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL5406214 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL5398480 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL5436416 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL5406147 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL5407780 | — | IC50 | = | 727.0 | nM | 6.14 |
| CHEMBL5420377 | — | IC50 | = | 738.0 | nM | 6.13 |
| CHEMBL5408329 | — | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL5403629 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5424286 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5422337 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5428915 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5408283 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5428441 | — | IC50 | = | 0.005 | nM | - |
| CHEMBL5404561 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5421080 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5405758 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5420266 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5440228 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5413228 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5407079 | — | IC50 | > | 1000.0 | nM | - |