Assay Detail
Functional
CHEMBL5336082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity in human MIA PaCa-2 cells assessed as intracellular NAD+ depletion incubated for 24 hrs by enzymatic cycling assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 9.08 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413890 | — | — | 1 | 9.85 |
| CHEMBL5431155 | — | — | 1 | 9.77 |
| CHEMBL5433246 | — | — | 1 | 9.70 |
| CHEMBL5428441 | — | — | 1 | 9.60 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.47 |
| CHEMBL5396894 | — | — | 1 | 9.37 |
| CHEMBL5409679 | — | — | 1 | 9.30 |
| CHEMBL5421145 | — | — | 1 | 9.06 |
| CHEMBL5417778 | — | — | 1 | 8.85 |
| CHEMBL5416318 | — | — | 1 | 8.83 |
| CHEMBL5439639 | — | — | 1 | 8.82 |
| CHEMBL5418853 | — | — | 1 | 8.70 |
| CHEMBL5422822 | — | — | 1 | 8.63 |
| CHEMBL5406214 | — | — | 1 | 8.33 |
| CHEMBL5441013 | — | — | 1 | 7.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413890 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL5431155 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5433246 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5428441 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5396894 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL5409679 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5421145 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL5417778 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL5416318 | — | IC50 | = | 1.48 | nM | 8.83 |
| CHEMBL5439639 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5418853 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5422822 | — | IC50 | = | 2.36 | nM | 8.63 |
| CHEMBL5406214 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL5441013 | — | IC50 | = | 11.25 | nM | 7.95 |