Assay Detail
Functional
CHEMBL5336089
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Cytotoxicity against human RPMI-8226 cells assessed as inhibition of cell viability at 72 hrs by SRB assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.99 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428441 | — | — | 1 | 9.80 |
| CHEMBL5421145 | — | — | 1 | 9.57 |
| CHEMBL5416318 | — | — | 1 | 9.33 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.12 |
| CHEMBL5433246 | — | — | 1 | 8.72 |
| CHEMBL5413890 | — | — | 1 | 8.67 |
| CHEMBL5396894 | — | — | 1 | 7.70 |
| CHEMBL5406214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428441 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5421145 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL5416318 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL5433246 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5413890 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL5396894 | — | IC50 | = | 20.15 | nM | 7.70 |
| CHEMBL5406214 | — | IC50 | - | — | - |