Assay Detail
Functional
CHEMBL5336097
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Antitumor activity in human ML-2 cells assessed as inhibition of intracellular NAD+ level measured after 24 hrs by enzymatic cycling assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ML-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of new nicotinamide phosphoribosyltransferase inhibitors with antitumor activity on solid and haematological cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 10.10 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421145 | — | — | 1 | 10.30 |
| CHEMBL5416318 | — | — | 1 | 10.05 |
| CHEMBL5428441 | — | — | 1 | 9.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421145 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL5416318 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5428441 | — | IC50 | = | 0.11 | nM | 9.96 |