Assay Detail
Binding
CHEMBL5336135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Calpain-1 using DABCYL-TPLKSPPPSPR-EDANS fluorogenic peptide as substrate pre-incubated for 30 mins in presence of GSH followed by substrate addition measured after 30 mins by FRET assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2365410 | — | — | 2 | 7.80 |
| CHEMBL4590273 | — | — | 2 | - |
| CHEMBL5436771 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2365410 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2365410 | — | IC50 | = | 16.22 | nM | 7.79 |
| CHEMBL4590273 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL4590273 | — | IC50 | < | 301995.17 | nM | - |
| CHEMBL5436771 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL5436771 | — | IC50 | < | 301995.17 | nM | - |