Assay Detail
Binding
CHEMBL5336209
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Inhibition of CDK12/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo luminescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development, validation, and evaluation of a deep learning model to screen cyclin-dependent kinase 12 inhibitors in cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.64 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4632717 | — | — | 1 | 7.28 |
| CHEMBL4468670 | — | — | 1 | 7.13 |
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | — | 1 | 6.84 |
| CHEMBL4163879 | — | — | 1 | 6.82 |
| CHEMBL4077071 | — | — | 1 | 6.74 |
| CHEMBL5420867 | — | — | 1 | 6.58 |
| CHEMBL4762845 | — | — | 1 | 6.37 |
| CHEMBL468963 | GW779439X | — | 1 | 6.36 |
| CHEMBL3672295 | — | — | 1 | 6.14 |
| CHEMBL5420897 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4632717 | — | IC50 | = | 52.97 | nM | 7.28 |
| CHEMBL4468670 | — | IC50 | = | 74.39 | nM | 7.13 |
| CHEMBL6291 | BISINDOLYLMALEIMIDE IX | IC50 | = | 143.1 | nM | 6.84 |
| CHEMBL4163879 | — | IC50 | = | 152.1 | nM | 6.82 |
| CHEMBL4077071 | — | IC50 | = | 183.5 | nM | 6.74 |
| CHEMBL5420867 | — | IC50 | = | 260.4 | nM | 6.58 |
| CHEMBL4762845 | — | IC50 | = | 425.4 | nM | 6.37 |
| CHEMBL468963 | GW779439X | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL3672295 | — | IC50 | = | 726.7 | nM | 6.14 |
| CHEMBL5420897 | — | IC50 | = | 748.9 | nM | 6.13 |