Assay Detail
Toxicity
CHEMBL5336227
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Cytotoxicity against human CCD-986Sk cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CCD-986Sk |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Covalent fragment mapping of KRas<sup>G12C</sup> revealed novel chemotypes with in vivo potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.28 | 4.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385800 | — | — | 1 | 4.37 |
| CHEMBL4214264 | — | — | 1 | 4.28 |
| CHEMBL3265255 | — | — | 1 | 4.18 |
| CHEMBL4476113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385800 | — | IC50 | = | 42700.0 | nM | 4.37 |
| CHEMBL4214264 | — | IC50 | = | 52200.0 | nM | 4.28 |
| CHEMBL3265255 | — | IC50 | = | 66200.0 | nM | 4.18 |
| CHEMBL4476113 | — | IC50 | - | — | - |