Assay Detail
Functional
CHEMBL5336307
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Antiviral activity against SARS-CoV-2 variant Omicron BA.2 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.70 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5190754 | — | — | 1 | 7.77 |
| CHEMBL4854767 | — | — | 1 | 7.77 |
| CHEMBL5287068 | — | — | 1 | 7.77 |
| CHEMBL5427950 | — | — | 1 | 7.77 |
| CHEMBL5075209 | — | — | 1 | 7.77 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 1 | 7.66 |
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 7.66 |
| CHEMBL3427166 | — | — | 1 | 7.66 |
| CHEMBL213054 | — | — | 1 | 7.66 |
| CHEMBL5439525 | — | — | 1 | 7.66 |
| CHEMBL5173559 | — | — | 1 | 7.66 |
| CHEMBL5206501 | — | — | 1 | 7.66 |
| CHEMBL5191092 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5190754 | — | EC50 | = | 17.1 | nM | 7.77 |
| CHEMBL4854767 | — | EC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5287068 | — | EC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5427950 | — | EC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5075209 | — | EC50 | = | 17.1 | nM | 7.77 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL4777223 | PF-00835231 | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL3427166 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL213054 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL5439525 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL5173559 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL5206501 | — | EC50 | = | 21.7 | nM | 7.66 |
| CHEMBL5191092 | — | EC50 | = | 21.7 | nM | 7.66 |